Best Cannabis Strain for Euphoria: Elevate Your Mood

Many people use cannabis for the sensation of feeling high, better known as getting in the zone, euphoria, happiness, and mental clarity. Whatever you do whether you need an uplifting experience or you just need to unwind after a hectic day, there are strains of cannabis that are famous for causing a euphoria. Often rich in THC, these strains can provide a blissful experience, so they’re perfect for people looking for a good positive mental shift. As you’ll see in this article, we cover the best cannabis strains for euphoria and how they can help make you feel good.

How Cannabis Induces Euphoria

The activation of the brain’s reward system, which tends to ebb and flow, and can be linked to euphoria, is associated with the presence of cannabinoids, especially THc. The main psychoactive compound found in cannabis is THC, the stuff that makes users feel “high”. THC is consumed and binds to the CB1 receptors in the brain, which sends the dopamine neurotransmitter signaling the brain ‘pleasure and reward’. The chemical reaction leads to euphoria lifts your mood and eases stress.
There is a growing desire among some cannabis strains, which are bred to have higher concentrations of THC to produce an even more intense euphoric buzz. But it’s critical to seek out the ideal strain for that perfect euphoria because some will leave you feeling more energizing with a rush or even ecstatic, while others tend to be a little more euphoric, calming, and soothing.
The Best Cannabis for Euphoria

1. Green Crack

A Sativa dominant strain known for its energizing and euphoric effects, Green Crack has quickly become a favorite amongst users. Having THC of 15 percent to 25 percent, this strain is perfect for you if you need a boost of mental focus and positivity. Green Crack is a clear cerebral high, so it’s great for daytime use. What it does is boost mood, increase focus, and gives a general feeling of euphoria. Green Crack will lift your spirits whether you need to get creative in the first place or if you enjoy a good time for time.

2. Blue Dream

Blue Dub is a hybrid strain of Sativa and Indica. Blue Dream has THC levels of 17% to 24% which offer an uplifting and relaxing euphoria all at once. It’s perfect for people who want some good old-fashioned mental clarity and creative inspiration, and to top it all off with a good old-fashioned relaxing body high. People love it because of its smooth, blissful high that makes it a great smoke for socializing, relaxing or even a chill day. Additionally, it’s known to decrease anxiety and stress and make this an overall euphoric experience.

3. Pineapple Express

The second is Pineapple Express, which is just as potent, but more energetic and euphoric than most hybrids. The THC content of this strain is around 19 to 25% giving a potent and uplifting high. If you are someone looking for something to enhance your mood and feel more social then Pineapple Express is a good choice. It gives you a happy high and a body relaxation, calming effect. This is both a daytime and evening pipe choice that is sweet, and tropical in scent and has a balanced effect.

4. Lemon Haze

A Sativa dominant strain with a name that screams its fresh citrus aroma and an uplifting effect, Lemon Haze is famous. Lemon Haze includes THC levels of between 15 – 22% and produces a euphoric, cheerful, energetic high that helps you feel more joyous and focused. It’s a particularly helpful strain for those in need of a quick creative boost or to relieve some stress and lift their mood. A really good choice if you’re going to have to socialize or engage in outdoor activities, or to get all your ducks in a row with a positive attitude. In addition, the zesty lemon flavor makes it a favorite with many.

5. Durban Poison

Also a pure Sativa, Durban Poison is listed as being very strong and offers an invigorating high as well as strong euphoric effects. With its THC levels averaging up 15 – 20%, this is a fantastic choice for those looking to get a little uplifting, energetic, euphoric experience. Known for being able to produce powerful creative and focus-inducing highs at the same time eliciting happiness and mental clarity. Durban Poison will get you pumped for a busy day or put on a smile and a jolly high.

The Best Way to Choose the Best Cannabis Strain for Euphoria

When selecting a cannabis strain for euphoria, there are a few key factors to consider:
THC Content: Higher THC strains give you a more intense euphoric experience. The milder, more relaxed euphoria can be had from strains with moderate THC levels.

Sativa vs. Indica: Green Crack and Lemon Haze are usually sativa dominants and will give you an uplifting and energizing high while Indica dominant strains will bring you the full body feeling, in a relaxed way.

Flavor and Aroma: Creative thinking about how to incorporate the taste and smell of cannabis can make the overall experience better. It gives you pleasant fruity and citrus flavors and you get Strains like Pineapple Express and Lemon Haze.

Feel the Euphoria

Experience Joy Today
Ready to elevate your mood? Check out our selection of cannabis Strains including top choices for euphoria at Certamd. Go to Certamd and shop now for your perfect strain!

Conclusion

Cannabis is a great tool to help you feel euphoric, uplifted, more relaxed, and more mentally clean. Green Crack, Blue Dream, Pineapple Express, Lemon Haze, and Durban Poison, are strains on which if you want to uplift your mood and have a happy experience then, it’s the best. From energizing highs to calm euphoria, there’s a strain that can satisfy you on your day. For Highs and the uplift, visit CertaMD today to learn which cannabis strains provide the best euphoria.

CertaMD Editorial Team
CertaMD's Editorial Team consists of seasoned medical professionals and writers dedicated to delivering accurate, up-to-date health information, including insights on medical cannabis. With a commitment to excellence, they ensure content is both accessible and authoritative for healthcare consumers.

Important Medical Information & Disclaimers

Medical disclaimer

The information on this CertaMD page is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

All medical marijuana evaluations and recommendations through CertaMD are performed exclusively by licensed U.S. healthcare providers using secure telemedicine technology, in accordance with applicable state laws and regulations.

Always speak with a qualified physician or other licensed healthcare professional before making decisions about your health, changing existing medications, or starting any new treatment, including medical cannabis.

Source: FDA – Cannabis Research & Drug Approval Process

Individual results and treatment response

Medical cannabis does not work the same way for every patient. Symptom relief can depend on factors such as the type of product (THC/CBD ratio, route of administration), dose, frequency of use, underlying medical conditions, concurrent medications, and lifestyle variables like diet, stress, and sleep.

Because response and tolerability vary, ongoing follow-up with your CertaMD provider is important to review benefits, monitor side effects, and adjust your treatment plan safely over time.

Source: NIH – Therapeutic Effects of Cannabis and Cannabinoids

Possible risks and side effects

Like any therapeutic option, medical marijuana can cause side effects. Commonly reported effects include dry mouth, dizziness, fatigue, red or irritated eyes, increased appetite, headache, and temporary problems with attention, concentration, or short-term memory.

Some patients, especially with higher-THC products, may experience anxiety, rapid heartbeat, worsened mood, or perceptual changes; in rare cases, serious effects such as psychosis, significant mood changes, heart rhythm disturbances, or cannabinoid hyperemesis syndrome (recurrent nausea and vomiting) have been reported. If you notice severe, unexpected, or persistent symptoms, stop using cannabis and contact your healthcare provider or seek urgent care.

Source: Mayo Clinic – Marijuana: Safety and Side Effects

Legal and regulatory notice

Medical marijuana programs are created and regulated at the state level, and eligibility, product access, and telemedicine rules vary by jurisdiction. Under U.S. federal law, marijuana remains a Schedule I controlled substance, and clinicians typically “recommend” or “certify” medical cannabis use rather than prescribe it in the traditional sense.

Some states require an initial in-person visit before medical cannabis certification, while others allow both initial and renewal evaluations via telehealth; CertaMD operates within the specific requirements of each state it serves.

Sources: DEA – Controlled Substances Act

Telehealth.org – Cannabis Prescribing and Telehealth

Product quality, sourcing, and safety

For your safety, use only medical cannabis products obtained from licensed, state-regulated dispensaries that perform appropriate laboratory testing for potency and contaminants. Unregulated or illicit products may contain pesticides, heavy metals, microbes, or inaccurate THC/CBD concentrations, which can increase health risks and lead to unpredictable effects.

Ask your CertaMD clinician or dispensary pharmacist about product selection, dosing, onset and duration of effects, and how to store products safely away from children and pets.

Source: FDA – What to Know About Cannabis Products

Reporting adverse events and safety concerns

If you experience serious or unexpected side effects while using medical cannabis, contact your healthcare provider immediately or seek emergency care when appropriate.

Patients and caregivers in the United States can also report adverse events and product problems to the FDA’s MedWatch program online or by phone at
1-800-FDA-1088, which helps regulators monitor safety trends and protect public health.

Source: FDA – MedWatch Safety & Adverse Event Reporting

See how much you could save with a medical card

Note that this is an estimate of savings and does not constitute a guarantee. Additional taxes in your area or recent changes in local laws may affect these rates. Please verify current regulations in your state.

Table of Contents

Latest Posts

How to Get & Renew a Medical Marijuana Card in California​

California is famous for its sunny weather and for being the first state to legalize medical cannabis. Today, you can walk into a store and...

How to Get & Renew a Medical Marijuana Card in Arizona​

Living in Arizona means you have choices when it comes to cannabis. You might see recreational dispensaries everywhere and wonder why you need a medical...
Top 10 Easy-to-Grow Strains

Top 10 Easy-to-Grow Strains

Choosing the right strain is huge if you are new to growing cannabis or looking to make your cultivation process easier. But some strains are...
Top 10 Uplifting And Energetic Strains

Top 10 Uplifting And Energetic Strains

While it’s common to attribute cannabis to its ability to relax, soothe, and calm, it’s also known for giving your mind and body a boost...
Top 10 Best Strains For Making Hash Or Concentrates

Top 10 Best Strains For Making Hash Or Concentrates

They come in the form of cannabis concentrates: hash. From a more seasoned cannabis enthusiast to a novice just dabbing their toes into concentrates, choosing...
Top 10 Medical Strains with High CBD Percentage

Top 10 Medical Strains with High CBD Percentage

Due to their potential health benefits, cannabis strains with high CBD content have come to the front of the line with the medical community. A...