Best Cannabis Strains for Autoimmune Disease Natural Relief

Best Cannabis Strains for Autoimmune Disease: Natural Relief

Autoimmune diseases occur when there is an attack on healthy cells by a person’s immune system, and the cells are not killed. Other conditions, like rheumatoid arthritis, lupus, and multiple sclerosis, can really affect someone’s quality of life and make some of the everyday things challenging to manage. However, traditional medications can also help, and now, many people are starting to turn to cannabis for its potential to reduce inflammation, ease pain and deliver symptom relief. Through this article, we dive deep into the best cannabis strains to help reduce symptoms of autoimmune disease and live healthier overall.

Cannabis and Autoimmune Disease

The plant cannabis contains powerful compounds called cannabinoids, chief among them THC and CBD, which work with the body’s own endocannabinoid system. Regulation of inflammation, immune function, and pain perception is also played by this system. Analgesic (pain relieving) properties of THC and anti-inflammatory and immunomodulatory (reducing the inflammation, improving the immune response) properties of CBD are known. Together, these cannabinoids can offer much-needed relief from many of the painful symptoms that come with autoimmune disease.
Consequently, when looking for cannabis strains that will provide relief from autoimmune disease, you should find an optimal ratio between THC and CBD as they complement each other. The strain with more CBD will offer better gentler and longer relief, not as much as intense psychoactive, while THC dominant strain will bring quick fast pain relief and muscle relaxation.
I’ve written a guide listing the Best Cannabis Strains for Autoimmune Disease.

1. ACDC

ACDC is a high CBD, low THC strain that has gained wide popularity among people seeking relief from autoimmune-associated chronic inflammatory pain. Acidophilus regular aka ACDC delivers some powerful anti-inflammation health benefits with up to 20% CBD, with very low to no THC, and no intense psychoactive high. This is exactly what you need if you wish to reduce pain but not lose your mind. People living with rheumatoid arthritis and multiple sclerosis often look to ACDC as a go-to strain.

2. Harlequin

Harlequin is a balanced hybrid strain with a 5:An excellent choice for the relief of autoimmune disease is a 2 ratio of CBD to THC. Made up of 10-15% THC and 10-15% CBD, Harlequin has a moderate THC and high CBD level, helping alleviate pain and reduce inflammation in the user without getting them stoned. If you have conditions such as lupus or fibromyalgia, then this strain is great for getting rid of the pain and stiffness, keeping relaxed, and improving your mood, this is a strain that is perfect for you.

3. Cannatonic

One of the newer strains creating a buzz is Cannatonic, a hybrid with high levels of CBD and very low THC, both of which can relieve autoimmune symptoms naturally without the psychoactive effects. Cannatonic is known for its pain-reducing ability and reducing inflammation, thus a great help to those with rheumatoid arthritis, multiple sclerosis, and other similar autoimmune diseases. Cannatonic can also promote sleep quality which is important for the treatment of autoimmune conditions.

4. OG Kush

Old growth is a classic hybrid strain famous for its pain-relieving properties. Having a THC content of approximately 18-20%, it is potent enough to treat inflammation and in some cases to act against the chronic pain associated with autoimmune diseases. Because of OG Kush’s full body relaxation effects, it can help ease muscle spasms and improve mobility consequently making OG Kush a preferred option for those suffering from conditions like multiple sclerosis. It can also draw out the stress and anxiety that are often present with chronic illness.

5. Charlotte’s Web

Charlotte’s Web, is a high CBD strain that has garnered acclaim for providing support for conditions such as chronic pain, inflammation and other conditions related to autoimmune diseases. Like most cannabis strains, this one has a very low THC content, which makes it ideal for people who don’t wish to get high. Infants, children and particularly individuals with autoimmune diseases such as rheumatoid arthritis and Crohn’s disease really seem to love Charlotte’s Web because it’s good for both inflammation and pain reduction and a good general feeling.

Autoimmune Disease and How to Choose the Best Cannabis Strain

When choosing a cannabis strain for autoimmune disease relief, consider the following factors:
CBD to THC Ratio: Strains with high CBD content are great for their ability to reduce inflammation as well as little pain relief without the risk of psychoactive effects. Not all of them, however, are equally effective, and for quick relief, THC-dominant strains can work better.
Strain Type: Those with autoimmune conditions will find Indica strains such as Cannatonic and OG Kush relax and pain relieving, ideal strains for them. Sativa strains are known to give more energy but can focus on helping your mood and fatigue as well.
Effect Preferences: Indica strains tend to be calming and relaxing; Hybrid strains may be a more balanced high, while other individuals may like to take something a little more calming.

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Conclusion

I have found great promise in cannabis being useful to help manage some of the symptoms of autoimmune diseases including chronic pain, inflammation, and fatigue. ACDC, Harlequin, Cannatonic, OG Kush, and Charlotte’s Web strains all possess different benefits such as reducing inflammation, itchy skin, and pain. Cannabis can have a large impact on your quality of life whether you’re seeking a high CBD strain to avoid the psychoactive effects of THC, or a balanced hybrid for immediate relief. For natural wellness, check out the best cannabis strains for autoimmune disease relief and visit CertaMD today.

CertaMD Editorial Team
CertaMD's Editorial Team consists of seasoned medical professionals and writers dedicated to delivering accurate, up-to-date health information, including insights on medical cannabis. With a commitment to excellence, they ensure content is both accessible and authoritative for healthcare consumers.

Important Medical Information & Disclaimers

Medical disclaimer

The information on this CertaMD page is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

All medical marijuana evaluations and recommendations through CertaMD are performed exclusively by licensed U.S. healthcare providers using secure telemedicine technology, in accordance with applicable state laws and regulations.

Always speak with a qualified physician or other licensed healthcare professional before making decisions about your health, changing existing medications, or starting any new treatment, including medical cannabis.

Source: FDA – Cannabis Research & Drug Approval Process

Individual results and treatment response

Medical cannabis does not work the same way for every patient. Symptom relief can depend on factors such as the type of product (THC/CBD ratio, route of administration), dose, frequency of use, underlying medical conditions, concurrent medications, and lifestyle variables like diet, stress, and sleep.

Because response and tolerability vary, ongoing follow-up with your CertaMD provider is important to review benefits, monitor side effects, and adjust your treatment plan safely over time.

Source: NIH – Therapeutic Effects of Cannabis and Cannabinoids

Possible risks and side effects

Like any therapeutic option, medical marijuana can cause side effects. Commonly reported effects include dry mouth, dizziness, fatigue, red or irritated eyes, increased appetite, headache, and temporary problems with attention, concentration, or short-term memory.

Some patients, especially with higher-THC products, may experience anxiety, rapid heartbeat, worsened mood, or perceptual changes; in rare cases, serious effects such as psychosis, significant mood changes, heart rhythm disturbances, or cannabinoid hyperemesis syndrome (recurrent nausea and vomiting) have been reported. If you notice severe, unexpected, or persistent symptoms, stop using cannabis and contact your healthcare provider or seek urgent care.

Source: Mayo Clinic – Marijuana: Safety and Side Effects

Legal and regulatory notice

Medical marijuana programs are created and regulated at the state level, and eligibility, product access, and telemedicine rules vary by jurisdiction. Under U.S. federal law, marijuana remains a Schedule I controlled substance, and clinicians typically “recommend” or “certify” medical cannabis use rather than prescribe it in the traditional sense.

Some states require an initial in-person visit before medical cannabis certification, while others allow both initial and renewal evaluations via telehealth; CertaMD operates within the specific requirements of each state it serves.

Sources: DEA – Controlled Substances Act

Telehealth.org – Cannabis Prescribing and Telehealth

Product quality, sourcing, and safety

For your safety, use only medical cannabis products obtained from licensed, state-regulated dispensaries that perform appropriate laboratory testing for potency and contaminants. Unregulated or illicit products may contain pesticides, heavy metals, microbes, or inaccurate THC/CBD concentrations, which can increase health risks and lead to unpredictable effects.

Ask your CertaMD clinician or dispensary pharmacist about product selection, dosing, onset and duration of effects, and how to store products safely away from children and pets.

Source: FDA – What to Know About Cannabis Products

Reporting adverse events and safety concerns

If you experience serious or unexpected side effects while using medical cannabis, contact your healthcare provider immediately or seek emergency care when appropriate.

Patients and caregivers in the United States can also report adverse events and product problems to the FDA’s MedWatch program online or by phone at
1-800-FDA-1088, which helps regulators monitor safety trends and protect public health.

Source: FDA – MedWatch Safety & Adverse Event Reporting

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