Best Weed Strain for Restless Leg Syndrome

Best Weed Strain for Restless Leg Syndrome

Restless Leg Syndrome (also known as RLS) is a neurological disorder that causes an uncontrollable urge to move your legs, accompanied often by uncomfortable sensations. This is a condition that tends to get worse around the evening or night, it’s hard to relax or sleep well. Cannabis has become a natural solution for many people for the symptoms of RLS. Some cannabis strains are known to counter muscle spasms, alleviate pain, relax the body, and make for better rest. Today we’ll go over some of the best cannabis strains for helping to combat Restless Leg Syndrome.

1. Granddaddy Purple

Noted for its deep relaxation effects, Granddaddy Purple (GDP) is fairly famous as an indica strain for those with Restless Leg Syndrome. Because this strain is known for its powerful muscle relaxing properties, it helps relieve muscle tension and spasms, reducing tension in your legs and making sleep easy.

Another effect of Granddaddy Purple is that it provides some calming effect, which can assist in countering anxiety and improve overall well-being. The sedative qualities make it ideal for nighttime use, so that you can sleep tight through your RLS discomfort.

2. ACDC

ACDC is a high CBD strain with its benefits, relief from pain and discomfort, without psychoactive side effects that come when CBD is absorbed by THC. This strain is ideal for those with Restless Leg Syndrome who would like to use the strain to manage their symptoms during the day without feeling as if they are ‘too busy on the couch.’ ACDC assists in reducing muscle pain and spasms as well as giving a sense of being able to move your legs when they’re under constant demand to do something.

If you want something low key, non intoxicating and understated for how RLS makes you feel, ACDC is the way to go.

3. Northern Lights

A true indica classic, Northern Lights is an extremely sedating strain, producing powerful knockouts that aren’t overcome by sleep. Those with RLS problems that make it hard to sleep (due to leg tightness) should definitely try it. It helps take care of pain, relieve muscle spasms and create deep relaxation, which helps you fall asleep easier and stay asleep longer.

The soothing effects of this strain are perfect to help destress after a long day, settling both your body relaxing your muscles and your legs letting them relax allowing you to get the better part and fall asleep faster.

4. Harlequin

A sativa dominant strain with high levels of CBD and perfect for dealing with the pain and discomfort that comes with Restless Leg Syndrome. He finds the intelligent balance of CBD to THC yields effective relief without the ‘high‘ effect. Harlequin is famous for being a great reduction of muscle tension, inflammation and nerve pain offering comfort and relaxation.

Harlequin enjoys a short combination of uplifting and calming and is thus suitable for daytime use without getting you drowsy as this helps you to stay active and pain free.

5. Blueberry

Classic indicia strain known for its calming and soothing effects, blueberry is a blueberry. Used for easing pain and muscle spasms common in Restless Leg Syndrome, it is a very effective remedy. Blue berry’s relaxing properties calm your nervous system and eliminate any urge to move your legs which makes it easy for you to lie back and relax.

It has the best results when used during the evening as its sedative effects could probably help you to wind down easier and have a deep restful sleep.

Discover Your Relief

Looking to get relief from Restless Leg Syndrome? If you are in search of the best strains to help alleviate discomfort, ease physical pain, or encourage relaxation and better sleep go to Certamd and browse through a treasure trove of curated strains.

Conclusion

Often, Restless Leg Syndrome can be easily and naturally treated with cannabis. Granddaddy Purple, ACDC, Northern Lights, Harlequin, and Blueberry strains have targeted relief that quality helps to ease spams, ease the discomfort, and give a better sleep. You can choose the right strain and get to relax and rest comfortably. Look into these options in order to choose the right cannabis strain to help treat your RLS and take advantage of natural relief.

CertaMD Editorial Team
CertaMD's Editorial Team consists of seasoned medical professionals and writers dedicated to delivering accurate, up-to-date health information, including insights on medical cannabis. With a commitment to excellence, they ensure content is both accessible and authoritative for healthcare consumers.

Important Medical Information & Disclaimers

Medical disclaimer

The information on this CertaMD page is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

All medical marijuana evaluations and recommendations through CertaMD are performed exclusively by licensed U.S. healthcare providers using secure telemedicine technology, in accordance with applicable state laws and regulations.

Always speak with a qualified physician or other licensed healthcare professional before making decisions about your health, changing existing medications, or starting any new treatment, including medical cannabis.

Source: FDA – Cannabis Research & Drug Approval Process

Individual results and treatment response

Medical cannabis does not work the same way for every patient. Symptom relief can depend on factors such as the type of product (THC/CBD ratio, route of administration), dose, frequency of use, underlying medical conditions, concurrent medications, and lifestyle variables like diet, stress, and sleep.

Because response and tolerability vary, ongoing follow-up with your CertaMD provider is important to review benefits, monitor side effects, and adjust your treatment plan safely over time.

Source: NIH – Therapeutic Effects of Cannabis and Cannabinoids

Possible risks and side effects

Like any therapeutic option, medical marijuana can cause side effects. Commonly reported effects include dry mouth, dizziness, fatigue, red or irritated eyes, increased appetite, headache, and temporary problems with attention, concentration, or short-term memory.

Some patients, especially with higher-THC products, may experience anxiety, rapid heartbeat, worsened mood, or perceptual changes; in rare cases, serious effects such as psychosis, significant mood changes, heart rhythm disturbances, or cannabinoid hyperemesis syndrome (recurrent nausea and vomiting) have been reported. If you notice severe, unexpected, or persistent symptoms, stop using cannabis and contact your healthcare provider or seek urgent care.

Source: Mayo Clinic – Marijuana: Safety and Side Effects

Legal and regulatory notice

Medical marijuana programs are created and regulated at the state level, and eligibility, product access, and telemedicine rules vary by jurisdiction. Under U.S. federal law, marijuana remains a Schedule I controlled substance, and clinicians typically “recommend” or “certify” medical cannabis use rather than prescribe it in the traditional sense.

Some states require an initial in-person visit before medical cannabis certification, while others allow both initial and renewal evaluations via telehealth; CertaMD operates within the specific requirements of each state it serves.

Sources: DEA – Controlled Substances Act

Telehealth.org – Cannabis Prescribing and Telehealth

Product quality, sourcing, and safety

For your safety, use only medical cannabis products obtained from licensed, state-regulated dispensaries that perform appropriate laboratory testing for potency and contaminants. Unregulated or illicit products may contain pesticides, heavy metals, microbes, or inaccurate THC/CBD concentrations, which can increase health risks and lead to unpredictable effects.

Ask your CertaMD clinician or dispensary pharmacist about product selection, dosing, onset and duration of effects, and how to store products safely away from children and pets.

Source: FDA – What to Know About Cannabis Products

Reporting adverse events and safety concerns

If you experience serious or unexpected side effects while using medical cannabis, contact your healthcare provider immediately or seek emergency care when appropriate.

Patients and caregivers in the United States can also report adverse events and product problems to the FDA’s MedWatch program online or by phone at
1-800-FDA-1088, which helps regulators monitor safety trends and protect public health.

Source: FDA – MedWatch Safety & Adverse Event Reporting

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