Best Cannabis Strains for Anxiety Relief

Best Cannabis Strains for Anxiety Relief

Mental health conditions such as anxiety is very common and affect millions of people around the world. So whether it’s generalized anxiety disorder, social anxiety or, say, temporary stress, natural ways to beat anxiety can be a life changer. With its mind and body-calming effects, medical cannabis has become popular as an alternative treatment for anxiety. Here we highlight the best cannabis strains for anxiety relief and how they can bring you relief from anxiety.

How Cannabis Helps Reduce Anxiety

Active compounds called cannabinoids exist in cannabis: the most common ones are THC (tetrahydrocannabinol) and CBD (cannabidiol). These cannabinoids interfere with your body’s endocannabinoid system (ECS), the branching of your central nervous system that is vital for things like stress responses and overall mental health. Here’s how cannabis can help alleviate anxiety:

  • Reduces stress: Reducing cortisol, the stress hormone, can reduce anxiety, and cannabinoids can do that.
  • Promotes relaxation: Some strains would also have a sedative action that would help calm the mind and relax the body.
  • Improves sleep: Specific strains can also improve the quality of sleep for people with anxiety-induced insomnia.
  • Uplifts mood: Mood-improving strains with rich CBD, without the psychoactive effects of THC.

Top Cannabis Strains for Anxiety Relief

1. Harlequin: High-CBD, Low-THC Strain

Harlequin, a sativa dominant, is one of the highest CBD strains known on the market as it is perfect for those looking for anxiety relief without the psychoactive effects of THC. They’re ideal for daytime use and offer clear-headed relaxation.

Why Harlequin?

  • Reduces anxiety: CBD-rich to THC ratio is high enough to reduce anxiety without a high.
  • Mood booster: That gives you a gentle uplift in mood, without clouding your mind.
  • Anti-inflammatory: It’s great for reducing physical tension and stress.

2. ACDC: CBD-Dominant Hybrid

Another high CBD strain used therapeutically is ACDC. Compared to many psychoactive strains, ACDC has hardly any THC and offers anxiety relief without the intoxication.

Why ACDC?

  • Non-psychoactive: Doesn’t decrease mental clarity.
  • Calming effects: It helps to lessen anxiety and helps to create a feeling of calm.
  • Reduces stress: They are great for patients who desire to keep their stress and anxiety under control throughout the day.

3. Granddaddy Purple:

Granddaddy Purple (GDP) is a potent indica strain for those who are suffering from anxiety, and often insomnia and it provides deep relaxation and stress relief for those who are struggling with these issues. Best for unwinding after a long day, and having a good night’s sleep.

Why Granddaddy Purple?

  • Sedative effects: It helps you relax and sleep faster.
  • Alleviates stress: It is known for its strong calming properties, and hence it should be used in the evening.
  • Relieves muscle tension: It’s also great for easing the physical symptoms of anxiety such as muscle tightness.

The best ways to take cannabis for anxiety.

How you consume marijuana affects how it can effectively treat anxiety. Here are some popular options:

  • Vaping or Smoking: Quick relief but short-lived effects.
  • Edibles: But they last longer.
  • Tinctures and Oils: Precise dosing and fast absorption.
  • Capsules: It’s a discreet, convenient means to help get rid of anxiety during the day.

Consult your healthcare provider before using cannabis to determine what strain and dosage is right for you.

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Conclusion

The good news is, that medical cannabis may offer a good natural solution for dealing with anxiety. Popular strains because of their calming and mood-enhancing properties include Harlequin, ACDC, and Granddaddy Purple. If you use the right strain or the preferred way of consuming it, you can easily take the strain of anxiety off your shoulders and enjoy your quality of life. Before starting any new treatment regimen, check with a healthcare professional. For more information and advice tailored specifically to your situation visit certamd.com.

 

CertaMD Editorial Team
CertaMD's Editorial Team consists of seasoned medical professionals and writers dedicated to delivering accurate, up-to-date health information, including insights on medical cannabis. With a commitment to excellence, they ensure content is both accessible and authoritative for healthcare consumers.

Important Medical Information & Disclaimers

Medical disclaimer

The information on this CertaMD page is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

All medical marijuana evaluations and recommendations through CertaMD are performed exclusively by licensed U.S. healthcare providers using secure telemedicine technology, in accordance with applicable state laws and regulations.

Always speak with a qualified physician or other licensed healthcare professional before making decisions about your health, changing existing medications, or starting any new treatment, including medical cannabis.

Source: FDA – Cannabis Research & Drug Approval Process

Individual results and treatment response

Medical cannabis does not work the same way for every patient. Symptom relief can depend on factors such as the type of product (THC/CBD ratio, route of administration), dose, frequency of use, underlying medical conditions, concurrent medications, and lifestyle variables like diet, stress, and sleep.

Because response and tolerability vary, ongoing follow-up with your CertaMD provider is important to review benefits, monitor side effects, and adjust your treatment plan safely over time.

Source: NIH – Therapeutic Effects of Cannabis and Cannabinoids

Possible risks and side effects

Like any therapeutic option, medical marijuana can cause side effects. Commonly reported effects include dry mouth, dizziness, fatigue, red or irritated eyes, increased appetite, headache, and temporary problems with attention, concentration, or short-term memory.

Some patients, especially with higher-THC products, may experience anxiety, rapid heartbeat, worsened mood, or perceptual changes; in rare cases, serious effects such as psychosis, significant mood changes, heart rhythm disturbances, or cannabinoid hyperemesis syndrome (recurrent nausea and vomiting) have been reported. If you notice severe, unexpected, or persistent symptoms, stop using cannabis and contact your healthcare provider or seek urgent care.

Source: Mayo Clinic – Marijuana: Safety and Side Effects

Legal and regulatory notice

Medical marijuana programs are created and regulated at the state level, and eligibility, product access, and telemedicine rules vary by jurisdiction. Under U.S. federal law, marijuana remains a Schedule I controlled substance, and clinicians typically “recommend” or “certify” medical cannabis use rather than prescribe it in the traditional sense.

Some states require an initial in-person visit before medical cannabis certification, while others allow both initial and renewal evaluations via telehealth; CertaMD operates within the specific requirements of each state it serves.

Sources: DEA – Controlled Substances Act

Telehealth.org – Cannabis Prescribing and Telehealth

Product quality, sourcing, and safety

For your safety, use only medical cannabis products obtained from licensed, state-regulated dispensaries that perform appropriate laboratory testing for potency and contaminants. Unregulated or illicit products may contain pesticides, heavy metals, microbes, or inaccurate THC/CBD concentrations, which can increase health risks and lead to unpredictable effects.

Ask your CertaMD clinician or dispensary pharmacist about product selection, dosing, onset and duration of effects, and how to store products safely away from children and pets.

Source: FDA – What to Know About Cannabis Products

Reporting adverse events and safety concerns

If you experience serious or unexpected side effects while using medical cannabis, contact your healthcare provider immediately or seek emergency care when appropriate.

Patients and caregivers in the United States can also report adverse events and product problems to the FDA’s MedWatch program online or by phone at
1-800-FDA-1088, which helps regulators monitor safety trends and protect public health.

Source: FDA – MedWatch Safety & Adverse Event Reporting

See how much you could save with a medical card

Note that this is an estimate of savings and does not constitute a guarantee. Additional taxes in your area or recent changes in local laws may affect these rates. Please verify current regulations in your state.

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